10Z-Hymenialdisine for cell activation

Catalog number
2212-1000
Name
10Z-Hymenialdisine for cell activation
Size
1 mg
Price
567.00 EUR
Supplier

Details

Description
Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC₅₀ = 6nM). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-β (GSK-3β) and CDK5/p35 in Alzheimer’s disease. Inhibitor of DNA damage checkpoint at G2 phase (IC₅₀ = 6 µM), cyclin-dependent kinases CDK1/cyclin B (IC₅₀ = 22 nM), CDK2/cyclin A (IC₅₀= 70 nM), CDK2/cyclin E (IC₅₀= 40 nM), CDK4/cyclin D1 (IC₅₀ = 600 nM), CDK5/p25 (IC₅₀ = 28 nM), GSK-3β (IC₅₀ = 10 nM), and casein kinase 1 (CK1) (IC₅₀ = 35 nM).
Peptide sequence
N/A
CAS number
82005-12-7
Molecular weight
324.13
Category
Biochemicals
Other name
4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one; Hymenialdisine
Molecular formula
C₁₁H₁₀BrN₅O₂
Physical appearance
Yellow oil
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥97% by HPLC
Reconstitute instructions
DMSO (5 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24months
Storage instructions
Protect from air and light
Additional description
For cells, cell lines and tissues in culture till half confluency.