Procathepsin K, rat recombinant

Catalog number
1029-1000
Name
Procathepsin K, rat recombinant
Size
1 mg
Price
8696.00 EUR
Supplier

Details

Target
Procathepsin K
Background
Cathepsin K, a member of the papain cysteine proteinase family, is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is produced as an inactive proenzyme (35.4 kDa) that is converted to its mature active form (23.5 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.
Concentration
1 mg/ml
Molecular weight
35.4 kDa
Synonym
CTSK, CTSO, CTSO3
Other name
CTSK, CTSO, CTSO3
NCBI gene number
25425
NCBI gene
CATK
Gene source
Rat
NCBI number
P00786
Recombinant
Yes
Source
E. coli.
Purification
≥95%
Tested applications
SDS-PAGE, HPLC
Level of endotoxin
N/A
Tested activity
>400 mU/mg
Biological activity
The specific activity is>400 mU/mg (1U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit (Catalog # K141-100)
Reesults
>400 mU/mg
Binding ability
N/A
Unit
1 U = 1 µmole/min/mg
Storage condition
-80°C
Shipping under
Dry ice
Physical appearance
Liquid
Physical properties
1 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).
How to reconstitute
N/A
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Latin name
Rattus norvegicus
Additional source
Recombinants or rec. proteins
Group
recombinants