NAALDase Inhibitor, PMPA for cell activation

Catalog number
2478-5
Name
NAALDase Inhibitor, PMPA for cell activation
Size
5 mg
Price
142.00 EUR
Supplier

Details

Description
PMPA is a highly potent and selective inhibitor of NAALADase (N-acetylated-alpha-linked-acidic dipeptidase or glutamate carboxypeptidase II or GCPII) with a Ki value of 275 pM. Displays robust neuroprotective activity in both in vitro and in vivo models of ischemia.
Peptide sequence
N/A
CAS number
173039-10-6
Molecular weight
226.12
Category
Biochemicals
Other name
2-(Phosphonomethyl)pentane-1,5-dioi​c acid; PMPA
Molecular formula
C₆H₁₁O₇P
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
Yes
Purification
≥95% by NMR
Reconstitute instructions
H₂O (>20 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.