Tariquidar for cell activation

Catalog number
2853-10
Name
Tariquidar for cell activation
Size
10 mg
Price
213.00 EUR
Supplier

Details

Description
Tariquidar is a potent, specific, noncompetitive inhibitor of P-glycoprotein (P-gp) (Kd = 5.1 nM). Tariquidar inhibits the ATPase activity of P-gp, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both. At low concentrations, Tariquidar acts selectively as an inhibitor of P-gp and as a substrate of BCRP (breast cancer resistance protein). At much higher concentrations (≥100 nM). Tariquidar acts as an inhibitor of both P-gp and BCRP.
Peptide sequence
N/A
CAS number
206873-63-4
Molecular weight
646.73
Category
Biochemicals
Other name
N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide; XR9576, XR 9576, XR-9576,Tariquidar
Molecular formula
C₃₈H₃₈N₄O₆
Physical appearance
Light yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>6 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.