Phloretin for cell activation

Catalog number
9625-100
Name
Phloretin for cell activation
Size
100 mg
Price
153.00 EUR
Supplier

Details

Description
Phloretin is a natural phenol which inhibits a variety of transporters. It inhibits the monocarboxylate transporters MCT1 and MCT2 (IC₅₀ = 28 and 14 µM, respectively), restricting the rapid transport of monocarboxylates like lactate and pyruvate across the plasma membrane. Phloretin also blocks the sodium/D-glucose cotransporter (Ki = 86 µM) and the human concentrative nucleoside transporter 3 (Ki = 32 µM). Blocks L-type Ca²⁺ channels; activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers.
Peptide sequence
N/A
CAS number
60-82-2
Molecular weight
274.27
Category
Biochemicals
Other name
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone; NSC 407292; RJC 02792
Molecular formula
C₁₅H₁₄O₅
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>25 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.