IC261 for cell activation

IC261 is a reversible, ATP-competitive inhibitor of casein kinase 1 (CK1) (IC₅₀ = ~1 µM for CK1δ and CK1ɛ and 16 µM for CK1α). It is at least 100-fold less effective against PKA, p34cdc2, and p55fyn. IC261, at 1 µM, inhibits cytokinesis in primary mouse embryo fibroblasts. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. 

N/A

186611-52-9 

311.34

Biochemicals

 (E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one; SU-5607

C₁₈H₁₇NO₄

Yellow solid

N/A

No

Yes

≥98% by HPLC

DMSO (>10 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.