PRT4165 for cell activation

Catalog number
B1054-5
Name
PRT4165 for cell activation
Size
5 mg
Price
142.00 EUR
Supplier

Details

Description
PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX. In addition, it prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α). 
Peptide sequence
N/A
CAS number
31083-55-3
Molecular weight
235.24
Category
Biochemicals
Other name
2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione; NSC600157
Molecular formula
C₁₅H₁₉NO₂
Physical appearance
Yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>20 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.