5-Aza-2'-deoxycytidine for cell activation

Catalog number
1754-10
Name
5-Aza-2'-deoxycytidine for cell activation
Size
10 mg
Price
159.00 EUR
Supplier

Details

Description
An epigenetic modifier. Decitabine is an analogue of the nucleoside 2’-deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. DNA hypomethylation is achieved at concentrations below those required to significantly inhibit DNA synthesis, which may promote restoration of function to genes associated with control of cellular differentiation and proliferation.
Peptide sequence
N/A
CAS number
2353-33-5
Molecular weight
228.08
Category
Biochemicals
Other name
4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-3,5-triazin-2(1H)-one; Decitabine
Molecular formula
C₈H₁₂N₄O₄
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (25 mg/ml), 50% acetic acid (25 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.