Azamulin for cell activation

Catalog number
2915-1
Name
Azamulin for cell activation
Size
1 mg
Price
121.00 EUR
Supplier

Details

Description
Azamulin is a derivative of the antibiotic pleuromutilin. It is a highly selective inhibitor of the CYP3A family (IC50 = 0.03-0.24 μM as reported in Stresser et al., DMD, January 2004 vol. 32 no. 1 p105-112). Azamulin is a 15 and 13 fold more potent inhibitor of CYP3A4 compared to CYP3A5 or CYP3A7 respectively making it very useful for CYP3A4 activity assays and can be used as a benchmark in CYP3A4 inhibitor screening assays. It is at least 100 fold selective over other CYP isoforms (except CYP2J2 ~ 50-fold).
Peptide sequence
N/A
CAS number
76530-44-4
Molecular weight
478.65
Category
CYP inhibitor, Biochemicals
Other name
(5-Amino-1H-1,2,4-triazol-3-yl)thio]acetic acid (3aS,4R,5S,6R,8R,9R,9aR,10R)-6-ethyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester,14-O-(5-(2-Amino1,3,4-triazolyl)thioacetyl)dihydromutilin, Antibiotic TDM 85-530
Molecular formula
C₂₄H₃₈N₄O₄S
Physical appearance
White to beige powder
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~10 mg/ml), Acetonitrile (~4.8 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air, light and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.