2-Deoxy-D-Glucose for cell activation

Catalog number
B1048-100
Name
2-Deoxy-D-Glucose for cell activation
Size
100 mg
Price
110.00 EUR
Supplier

Details

Description
2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism. Upon transport into the cells, 2-DG is phosphorylated by hexokinase to 2-DG-P. However, unlike G-6-P, 2-DG-P cannot be further metabolized by phosphohexose isomerase, which converts G-6-P to fructose-6-phosphate . 2-Deoxyglucose-P is trapped and accumulated in the cells, leading to inhibition of glycolysis mainly at the step of phosphorylation of glucose by hexokinase. Inhibition of this rate-limiting step by 2-DG causes a depletion of cellular ATP, leading to blockage of cell cycle progression and cell death in vitro.
Peptide sequence
N/A
CAS number
154-17-6
Molecular weight
164.16
Category
Biochemicals
Other name
2-Deoxy-D-arabinohexose, 2-Deoxyglucose
Molecular formula
C₆H₁₂O₅
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% GC
Reconstitute instructions
H2O (>15 mg/ml) or DMSO (>15 mg/ml)
Storage condition
+4°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and moisture
Additional description
For cells, cell lines and tissues in culture till half confluency.