anti-Thioredoxin Reductase 2 Antibody (7B2)

Catalog number
anti-Thioredoxin Reductase 2 Antibody (7B2)
Thioredoxin Reductase 2 Antibody (7B2)
403.00 EUR


Target of this antibody:
Thioredoxin Reductase 2
Alternative names of antibody target:
Thioredoxin Reductase, GRIM-12, MGC9145, TR, TRXR2.
Background information:
The mammalian thioredoxin reductases (TrxRs) are a family of seleno-cysteine containing pyridine nucleotide-disulfide oxido-reductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate seleno-cysteine (SeCys) residue in the conserved sequence(-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55 – 58 kDa in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various biological phenomena. TrxR2 maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
Antibody host:
Clonality of antibody:
Mouse IgG 1
This antibody reacts with:
Immunogene sequence:
Recombinant human protein purified from E.coli
Concentration of antibody:
1 mg/ml
Form of antibody:
Formulation of this antibody:
100 µl of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol
Purification method:
Ammonium sulphate precipitation purified antibody
This antibody has been succesfully tested for use in following methods:
Western blot,IP
Recommended usage:
Western blot: 1:1000, IP: 1-2 µl.
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation