3-Deazaneplanocin A for cell activation

Catalog number
2060-250
Name
3-Deazaneplanocin A for cell activation
Size
250 µg
Price
137.00 EUR
Supplier

Details

Description
A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.
Peptide sequence
N/A
CAS number
102052-95-9
Molecular weight
262.26
Category
Biochemicals
Other name
DZNep; NSC 617989; 5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol
Molecular formula
C₁₂H₁₄N₄O₃
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
Yes
Purification
≥98%
Reconstitute instructions
DMSO (20 mg/ml) or EtOH (1 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Additional description
For cells, cell lines and tissues in culture till half confluency.