3-Deazaneplanocin A hydrochloride for cell activation

Catalog number
2444-250
Name
3-Deazaneplanocin A hydrochloride for cell activation
Size
250 µg
Price
126.00 EUR
Supplier

Details

Description
A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.
Peptide sequence
N/A
CAS number
120964-45-6
Molecular weight
298.73
Category
Biochemicals
Other name
DZNep; NSC 617989; 5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol hydrochloride
Molecular formula
C₁₂H₁₄N₄O₃. HCl
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
H₂O (~5 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and moisture
Additional description
For cells, cell lines and tissues in culture till half confluency.