anti-NCOA1 Antibody

Catalog number
6153-100
Name
anti-NCOA1 Antibody
Size
NCOA1 Antibody
Price
414.00 EUR
Supplier

Details

Target of this antibody:
NCOA1
Alternative names of antibody target:
NCOA1, F­SRC­1, KAT13A, MGC129719, MGC129720, NCoA­1, RIP160, SRC­1, SRC1, bHLHe42, bHLHe74, 6/G9a
Background information:
There are three members of the steroid receptor co­activator (SRC) family of proteins: SRC­1 (NCoA­1), SRC­2 (TIF2/GRIP1/NCoA­2), and SRC­3 (ACTR /TRAM­1/AIB1). All SRC family members share significant structural homology and function to stimulate transcription mediated by nuclear hormone receptors and other transcriptional activators such as Stat3, NF­κB, E2F1, and p53. Two SRC proteins, SRC­1 and SRC­3, function as histone acetyltransferases. In addition, all three family members can recruit other histone acetyltransferases (CBP/p300, PCAF) and histone methyltransferases (PRMT1, CARM1) to target promoters and cooperate to enhance expression of many genes. The SRC proteins play important roles in multiple physiological processes including cell proliferation, cell survival, somatic cell growth, mammary gland development, female reproductive function, and vasoprotection. SRC­1 and SRC­3 are conduits for kinase mediated growth factor signaling to the estrogen receptor and other transcriptional activators. Seven SRC­1 phosphorylation sites and six SRC­3 phosphorylation sites have been identified, which are induced by steroids, cytokines, and growth factors and involve multiple kinase signaling pathways. Research has shown that all three SRC family members are associated with increased activity of nuclear receptors in breast, prostate, and ovarian carcinomas. According to the literature, SRC­3 is frequently amplified or overexpressed in a number of cancers, and SRC­1/PAX3 and SRC­2/MYST3 translocations are found associated with rhabdomyosarcoma and acute myeloid leukemia, respectively.
Antibody host:
Rabbit
Clonality of antibody:
Polyclonal
Isotype:
Rabbit IgG
This antibody reacts with:
Human, mouse, rat
Immunogene sequence:
Recombinant protein of human NCOA1
Concentration of antibody:
1 mg/ml
Form of antibody:
Liquid
Formulation of this antibody:
100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Purification method:
Affinity purified
This antibody has been succesfully tested for use in following methods:
Western blot, Immunohistochemistry
Recommended usage:
Western blot: 1:500 – 1:2000, IHC: 1:50 – 1:200.
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps