Itraconazole for cell activation

Catalog number
1987-50
Name
Itraconazole for cell activation
Size
50 mg
Price
115.00 EUR
Supplier

Details

Description
A synthetic broad-spectrum triazole antifungal agent with the mode of action being through Inhibition of cytochrome P450 dependent enzymes including 14α-demethylase. Recently, it has been shown that Itraconazole inhibits Hedgehog (Hh) signaling pathway activity (IC50 = 0.8 µM) as well as blocks the VEGFR2 glycosylation, trafficking, and signaling in endothelial cells.
Peptide sequence
N/A
CAS number
84625-61-6
Molecular weight
705.63
Category
Biochemicals
Other name
(2R,4S)-rel-1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one; Oriconazole, R51211, Sporanox
Molecular formula
C₃₅H₃₈Cl₂N₈O₄
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
No
Purification
≥97%
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
60 months
Storage instructions
Protect from light and air
Additional description
For cells, cell lines and tissues in culture till half confluency.