Cathepsin K, Active, rat recombinant

Catalog number
7598-5
Name
Cathepsin K, Active, rat recombinant
Size
5 μg
Price
360.00 EUR
Supplier

Details

Target
Cathepsin K
Background
Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996).
Concentration
0.5 mg/ml
Molecular weight
23.5 kDa (115-329 aa)
Synonym
CTSK, CTSO, CTSO3
Other name
CTSK, CTSO, CTSO3
NCBI gene number
21975
NCBI gene
CTSK
Gene source
Rat
NCBI number
O35186
Recombinant
Yes
Source
E. coli
Purification
≥90%
Tested applications
SDS-PAGE, N/A
Level of endotoxin
N/A
Tested activity
The Cathepsin K is fully active as seen from its ability to cleave Cathepsin K-specific fluorescent substrate using the Cathepsin K Activity assay kit (Cat # K141-100).
Biological activity
The specific activity is>500 mU/mg (1U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit (Catalog #K141-100)
Reesults
The specific activity is>500 mU/mg (1U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit (Catalog #K141-100)
Binding ability
N/A
Unit
N/A
Storage condition
-80°C
Shipping under
Dry Ice
Physical appearance
Liquid
Physical properties
0.5 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.
How to reconstitute
N/A
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Gene
CTS protease activity also measured by zymograph electrophoresis of Cathepsins. This cathepsin is supplied in 1.
About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Latin name
Rattus norvegicus
Additional source
Recombinants or rec. proteins
Group
recombinants