(±)-Gossypol for cell activation

Catalog number
2579-50
Name
(±)-Gossypol for cell activation
Size
50 mg
Price
153.00 EUR
Supplier

Details

Description
Isolated from cotton seeds. It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans. Gossypol also has antimalarial properties, preventing the growth of P. falciparum at low micromolar concentrations. It inhibits aldose reductase (Ki = 0.5 µM).Gossypol also acts as an anticancer agent, inhibiting cell growth in various cancer cell lines, in part by blocking the anti-apoptotic functions of Bcl-2 and Bcl-xL, again at low micromolar concentrations. Also acts as a non-selective competitive inhibitor of NADH binding to LDH, with K(i) values of 1.9, 1.4, and 4.2 µM for LDH-A4, -B4, and -C4, respectively.
Peptide sequence
N/A
CAS number
303-45-7
Molecular weight
518.55
Category
Biochemicals
Other name
(±)-2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene; NSC 56817; NSC 524336; BL 193; Pogosin
Molecular formula
C₃₀H₃₀O₈
Physical appearance
Yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95%
Reconstitute instructions
DMSO (>10 mg/ml) or EtOH (>10 mg/ml with slight warming)
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.