(±)-Gossypol for cell activation

Catalog number
2579-250
Name
(±)-Gossypol for cell activation
Size
250 mg
Price
458.00 EUR
Supplier

Details

Description
Isolated from cotton seeds. It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans. Gossypol also has antimalarial properties, preventing the growth of P. falciparum at low micromolar concentrations. It inhibits aldose reductase (Ki = 0.5 µM).Gossypol also acts as an anticancer agent, inhibiting cell growth in various cancer cell lines, in part by blocking the anti-apoptotic functions of Bcl-2 and Bcl-xL, again at low micromolar concentrations. Also acts as a non-selective competitive inhibitor of NADH binding to LDH, with K(i) values of 1.9, 1.4, and 4.2 µM for LDH-A4, -B4, and -C4, respectively.
Peptide sequence
N/A
CAS number
303-45-7
Molecular weight
518.55
Category
Biochemicals
Other name
(±)-2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene; NSC 56817; NSC 524336; BL 193; Pogosin
Molecular formula
C₃₀H₃₀O₈
Physical appearance
Yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95%
Reconstitute instructions
DMSO (>10 mg/ml) or EtOH (>10 mg/ml with slight warming)
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Additional description
For cells, cell lines and tissues in culture till half confluency.