17-AAG for cell activation

Catalog number
1774-5
Name
17-AAG for cell activation
Size
5 mg
Price
588.00 EUR
Supplier

Details

Description
A semi-synthetic derivative of Geldanamycin (Cat. No. 1564-1,5) that displays greater stability and lower in vivo toxicity compared to Geldanamycin. Binds to Heat shock protein 90 (Hsp90) (EC₅₀ = 7.2 µM) in a manner similar to geldanamycin. Exhibits 100-fold higher affinity for tumor-derived Hsp90 over normal cells. Also inhibits Akt activation and HER2 expression in tumor cells.
Peptide sequence
N/A
CAS number
75747-14-7
Molecular weight
585.69
Category
Biochemicals
Other name
Telatinib; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)geldanamycin; Tanespimycin
Molecular formula
C₃₁H₄₃N₃O₈
Physical appearance
Purple solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (150 mg/ml) or EtOH (5 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Additional description
For cells, cell lines and tissues in culture till half confluency.