anti-p44/42 MAPK (Erk1/2) Antibody

p44/42 MAPK (Erk1/2)

MAPK1, p38, ERK , P42MAPK, ERK2 , p40 , PRKM1 , p41mapk , PRKM2, MAPK2 , p42-MAPK, p41 , ERK-2, ERT1

The extracellular signal-regulated kinase 1 and 2 (Erk1 and Erk2) are closely related mitogen activated protein (MAP) kinases that are activated throμgh the extracellular stimulation by many growth factors, mitogens and differentiation promoting agents via a protein kinase cascade. Erk1/2 are activated approximately 1000 fold by phosphorylation of neighboring threonine and tyrosine residues by Mek1 and Mek2. Both sites must be phosphorylated for maximum activity. Erk1/2 kinases are ubiquitously distributed in the nervous system, as well as a broad range of cells and tissues. These two kinases represent proximal kinases in the classical MAP kinase cascade pathway which links growth and differentiation signals at the cell surface (throμgh tyrosine kinase) with transcription in the nucleus.

Rabbit

Polyclonal

Rabbit IgG

Human, mouse, rat, sheep, chicken

Synthetic peptide surrounding amino acid 340 of rat ERK2/MAPK1

0.5 mg/ml

Liquid

100 µg (0.5 mg/ml) affinity purified rabbit anti- ERK2/MAPK1polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.

Affinity purified

Western blot

Western Blot analysis (1-4 µg/ml).

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps