anti-RIP3 Antibody

RIP3

RIP like protein kinase 3, RIPK3, RIPK3

Receptor interacting protein including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the c-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, and mediates TNF-R1 mediated apoptosis, and attenuates RIP and TNFR1 induced NFkB activation. Overexpression of RIP3 induces apoptosis and NFkB activation.

Rabbit

Polyclonal

Rabbit IgG

Mouse, rat

Synthetic peptide corresponding to residues surrounding amino acid 476 of mouse RIP3

0.5 mg/ml

Liquid

100 µg (0.5 mg/ml) immunoaffinity purified rabbit anti-RIP3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Affinity purified

Western blot, Immunohistochemistry

Western blotting (0.5-4 µg/ml) and in Immunohistochemistry (10-20 µg/ml). Rat kidney tissue section can be used as a positive control. An approximately 57 kDa band should be detected.

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps