anti-MMP-8 Antibody

MMP-8

120355 , P22894 , CLG1 , HNC, PMNL-CL , EC 3.4.24.34 , MMP-8 , Matrix metalloproteinase

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. Unlike other members of the MMP family, MMP-8 is expressed exclusively in inflammatory conditions. MMP-8 is also the predominant collagenase expressed in ulcers and healing wounds.

Rabbit

Polyclonal

Rabbit IgG

Human, mouse, rat

Synthetic peptide mapping to the hinge region of the human MMP-8 sequence

0.5 mg/ml

Liquid

100 µg (0.5 mg/ml) protein A affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.

Affinity purified

Western blot, Immunoprecipitation, Immunohistochemistry

Western blotting (1-4 µg/ml), immunoprecipitation (10-20 µg/ml), and Immunohistochemistry (15-25 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes latent (85 kDa) and active forms (25-65 kDa) of MMP8 from human, mouse, and rat origins.

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps