anti-TLR7 Antibody

TLR7

TLR7 , Anti-TLR7 , PRO285 , UNQ248

The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFkB and sμggests that these receptors are involved in mediating inflammatory responses. TLR6 and TLR7 induce NFkB signaling upon activation, sμggesting they play a role in immune reponse. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes.

Rabbit

Polyclonal

Rabbit IgG

Human

Synthetic peptide surrounding amino acid 468 of human TLR7

N/A

Liquid

100 µl affinity purified rabbit anti-TLR7 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.02% thimerosal.

Affinity purified

Western blot

Western blotting (1:500-1000 dilution). However, the optimal conditions should be determined individually. Ramos cell lysate can be used as a positive control.

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps