anti-PCSK9 Antibody

PSCK9

PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9

Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Rabbit

Polyclonal

Rabbit IgG

Human

Recombinant Human Cell Expressed Human PCSK9 Protein

N/A

Liquid

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH 7.0 with trehalose and 0.05% sodium azide as protectant before lyophilization.

Protein A/G purified

Western blot, ELISA

Western blot: 0.5 - 2.0 µg/ml, ELISA: 0.2 – 1 µg/ml

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps