anti-JMJD6 Antibody
Catalog number
6109-50
Name
anti-JMJD6 Antibody
Size
JMJD6 Antibody
Price
295.00 EUR
Supplier
Details
Target of this antibody:
JMJD6
Alternative names of antibody target:
Jumonji Domain Containing 6; PTDSR
Background information:
Tudor domains are small protein structural motifs of about ~50 amino acids related to the “royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification, and chromatin remodeling. The tudor domains recognize symmetric methylated arginine or methylated lysine residues. JMJD6 is a 403 amino acid nuclear protein lysyl-hydroxylase that has been reported to have arginine demethylase activity for histone H3 at ‘Arg-2’ and histone H4 at ‘Arg-3’. JMJD6 has been sμggested to function in the differentiation of multiple organs during embryogenesis and regulate hematopoietic differentiation and macrophage cytokine responses. First identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells, JMJD6 was later indicated not to directly function in the clearance of apoptotic cells. It is ubiquitously expressed in most tissues and is upregulated in patients with chronic pancreatitis and upon cytokine treatment, but not upon TNF-α treatment.
Antibody host:
Rabbit
Clonality of antibody:
Polyclonal
Isotype:
Rabbit IgG
This antibody reacts with:
Human, chimpanzee, bovine, canine, equine, mouse, opossum
Immunogene sequence:
Human recombinant JMJD2A aa 127-144
Concentration of antibody:
N/A
Form of antibody:
Liquid
Formulation of this antibody:
50 µg of antibody in 100 µl PBS containing 0.05% BSA and 0.05% sodium salt.
Purification method:
Antigen affinity purified
This antibody has been succesfully tested for use in following methods:
Western blot
Recommended usage:
Western blot: 0.25-1.0 µg/ml. However, the optimal conditions should be determined individually.
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps
