anti-TBLR1 Antibody

TBLR1

F-Box-Like/WD Repeat-Containing Protein; Transducin β-Like 1X-Related Protein 1

Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thoμght to mediate repression, at least in part, by their ability to recruit histone deacetylases (HDAC) to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes and its presence is thoμght to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Althoμgh TBLR1 is thoμght to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.

Rabbit

Polyclonal

Rabbit IgG

Human, mouse, rat

Synthetic peptide from human TBLR1 within the region of amino acids 200-250.

N/A

Liquid

50 µg of antibody in 100 µl PBS containing 0.2% gelatin and 0.05% sodium azide.

Protein G purified

Western blot

Western blot: 1-3 µg/ml. However, the optimal conditions should be determined individually.

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps