GM-CSF, rat recombinant

Granulocyte/Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-α

Granulocyte/Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-α, Colony-stimulating factor, Molgramostin, Sargramostim

A cytokine functioning as a white blood cell growth factor

GM-CSF

116630

CSF2

Rat

P48750

Yes

E. coli

≥98%

N/A

The ED₅₀ determined by the dose-dependent stimulation of the proliferation of murine FDC-P1 cells is 1 x 10⁸ units/mg.

14.5 kDa

-20°C

Gel pack

1 year

N/A

Lyophilized protein

Sterile filtered and lyophilized from 10 mM Tris, pH 8.5.

Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers or stored at 4°C for 1 week or –20°C for future use.

Centrifuge the vial prior to opening.

For Research Use Only! Not to be used in humans

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim. Reconstitution It is recommended that sterile ddH2O containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of not less than 1 mg/mL of the cytokine.

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

Rattus norvegicus

Recombinants or rec. proteins

recombinants