IGF-I, murine recombinant

Catalog number

4120-1000

Size

1 mg

Price

1500.00 EUR

Supplier

Biovision

Order

Details

Synonyms

Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF.

Alternates names

Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF.

Taglines

An endocrine hormone binding to IGF1R

Biomolecule/Target

IGF-I

NCBI Gene ID #.

16000

NCBI Gene Symbol

IGF1A

Gene Source

Mouse

Accession #

P05017

Recombinant

Yes

Source

E. coli

Purity

≥98%

Activity (Specifications/test method)

N/A

Biological activity

The ED₅₀ as determined by cell proliferation assay using FDC-P1 cells is 5 x 10⁵ units/mg. For most in vitro applications, the IGF-I exerts its biological activity in the concentration range of 1 to 20 ng/ml.

Molecular Weight

7.6 kDa

Storage Temp.

-20°C

Shipping

Gel pack

Shelf Life

1 year

Concentration

N/A

Appearance

Lyophilized protein

Physical form description

Sterile filtered and lyophilized with no additives

Reconstitution Instructions

Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Handling

Centrifuge the vial prior to opening.

Usage

For Research Use Only! Not to be used in humans

Description

IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.

Additional source

Recombinants or rec. proteins

Group

recombinants