IGF-II, human recombinant

Catalog number
4122-10
Name
IGF-II, human recombinant
Size
10 μg
Price
230.00 EUR
Supplier
Biovision
Order

Details

Synonyms
insln-like Growth Factor-II, Somatamedin A
Alternates names
insln-like Growth Factor-II, Somatamedin A, insln-like growth factor II Ala-25 Del, Preptin
Taglines
A growth promoting hormone during gestation
Biomolecule/Target
IGF-II
NCBI Gene ID #.
3481
NCBI Gene Symbol
IGF2
Gene Source
Human
Accession #
P01344
Recombinant
Yes
Source
E. coli
Purity
≥98%
Activity (Specifications/test method)
N/A
Biological activity
The recombinant human IGF-II is biologically active when compared to standard. The ED₅₀ as determined by competitive binding against plasma-derived IGF-II to human placental membranes is 1 x 10⁶ units/mg.
Molecular Weight
7.5 kDa
Storage Temp.
-20°C
Shipping
Gel pack
Shelf Life
1 year
Concentration
N/A
Appearance
Lyophilized protein
Physical form description
Lyophilized with no additives.
Reconstitution Instructions
Reconstitute in 10 mM acetic acid to a concentration of 0.1-1 mg/ml. This solution can be diluted into other aqueous buffers and or stored at 4°C for 1 week or –20°C for future use.
Handling
Centrifuge the vial prior to opening.
Usage
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description
IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.
Additional source
Recombinants or rec. proteins
Group
recombinants