anti-BICC1 Antibody (NT)

BICC1

BICC1; Protein bicaudal C homolog 1

BICC1, also known as protein bicaudal C homolog 1, is a 974 amino acid protein that belongs to the BICC family. BICC1 is considered a putative RNA-binding protein and may be involved in regulating gene expression during embryonic development by modulating protein translation. Existing as two alternatively spliced isoforms, BICC1 contains two KH domains as well as one SAM (sterile α motif) domain. Both BICC1 isoforms are widely expressed in normal tissues and are found in all brain regions including cerebral cortex, hippocampus and midbrain, although BICC1 isoform 1 is more highly expressed than isoform 2, particularly in nerve tissue. BICC1 can uncouple dishevelled-2 (Dvl-2) signaling from the canonical Wnt pathway in a SAM domain dependent manner, suggesting that the different BICC1 isoforms may play varying biological roles. Genetic variants in BICC1 may be involved in recurrent unipolar major depression. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.

Rabbit

Polyclonal

Rabbit IgG

N/A

Human

This BICC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the N-terminal region of human BICC1.

N/A

Liquid

100 µl of antibody in PBS with 0.09% (W/V) sodium azide

This antibody is purified through a protein A column, followed by peptide affinity purification.

Western blot, IHC

Western blot: ~1:1000, IHC: ~1:10–1:50.

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps