anti-HLA-DRA Antibody (Clone # 302CT2.3.2)
Catalog number
6792-50
Name
anti-HLA-DRA Antibody (Clone # 302CT2.3.2)
Size
HLA-DRA Antibody (Clone # 302CT2.3.2)
Price
316.00 EUR
Supplier
Details
Target of this antibody:
HLA-DRA
Alternative names of antibody target:
HLA-DRA; HLA-DRA1; HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA
Background information:
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II å/∫ dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (∫-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
Antibody host:
Mouse
Clonality of antibody:
Monoclonal
Isotype:
Mouse IgM
Clone:
Clone # 302CT2.3.2
This antibody reacts with:
Human.
Immunogene sequence:
This HLA-DRA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 48-75 amino acids from human HLA-DRA.
Concentration of antibody:
N/A
Form of antibody:
Liquid
Formulation of this antibody:
Crude ascites with 0.09% (W/V) sodium azide.
Purification method:
N/A
This antibody has been succesfully tested for use in following methods:
Western blot.
Recommended usage:
WB: 1:500 – 1:16000.
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps
