anti-Phospho-LC3C(S12) Antibody
Catalog number
6951-100
Name
anti-Phospho-LC3C(S12) Antibody
Size
Phospho-LC3C(S12) Antibody
Price
360.00 EUR
Supplier
Details
Target of this antibody:
LC3
Alternative names of antibody target:
MAP1LC3A; Microtubule-associated proteins 1A/1B light chain 3A; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; Microtubule-associated protein 1 light chain 3 alpha
Background information:
Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.
Antibody host:
Rabbit
Clonality of antibody:
Polyclonal
Isotype:
Rabbit Ig
This antibody reacts with:
Human. Predicted cross reactivity with bovine, mouse and rat samples.
Immunogene sequence:
This LC3C Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S12 of human LC3C.
Concentration of antibody:
N/A
Form of antibody:
Liquid
Formulation of this antibody:
Supplied in PBS with 0.09% (W/V) sodium azide.
Purification method:
Affinity Purified Antibody
This antibody has been succesfully tested for use in following methods:
Western Blot, Dot Blot
Recommended usage:
WB: ~1:1000, DB: 1:500.
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps
