anti-EPO Antibody

EPO

Erythropoietin-Alpha, EPO-a, EPO-alpha, Epoetin, EP, MGC138142

Human erythropoietin (EPO) is an acidic glycoprotein. It is mainly produced by the kidney. As the primary regulator of the production of red cells, its major functions are to promote erythroid progenitor cells differentiation and to start the synthesis of hemoglobin. EPO acts by binding to a specific erythropoietin receptor (EPOR) on target cells; the red cell precursors in the bone marrow, and induces their transformation into mature erythrocytes. The EPO sensitivity increases with differentiation of immature progenitor cells. EPO may act as a neuron protector against glutamate toxicity. Its neuroprotective activity comes into effect by neutralizing the toxicity of free radicals. EPO is produced in brain after oxidative stress. EPO is upregulated by hypoxia and prevents apoptosis of erythroid progenitors in bone.

Rabbit

Polyclonal

Rabbit Ig

Human

Human CellExp™ EPO, Human Recombinant (Cat # 6447)

1 mg/ml

Liquid

1 mg/ml in PBS with 0.007% (W/V) sodium azide

This antibody is purified through a protein A affinity chromatography.

Western blot

WB - 1:10,000-20,000

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps