anti-P-glycoprotein Antibody

P-glycoprotein

P-gp, Multidrug resistance protein 1, MDR1, ATP-binding cassette sub-family B (MDR/TAP) member 1, ABCB1

P-gp, also called MDR1 or ABCB1, is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of xenobiotics across extra- and intracellular membranes). It is an ATP-dependent drug efflux pump with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein functions in the kidneys, liver, blood–brain barrier and the intestinal epithelium.

Rabbit

Polyclonal

Rabbit Ig

N/A

Human, Mouse, Rat

Synthetic peptide corresponding to amino acids around position 630 of human P-glycoprotein

N/A

Lyophilized

Each vial contains 5mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3

Immunogen affinity purified antibody

IHC-P, IHC-F

IHC: 1:500-1:1000 of 0.5 mg/ml stock

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The vial should be centrifuged to collect the lyophilized solid before reconstituting

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps