anti-Cleaved-Caspase-1 Antibody

Catalog number
A1004-50
Name
anti-Cleaved-Caspase-1 Antibody
Size
Cleaved-Caspase-1 Antibody
Price
338.00 EUR
Supplier
Biovision
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Details

Target of this antibody:
Cleaved Caspase-1
Alternative names of antibody target:
CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, IL1BC, IL1BCE, CASP1
Background information:
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Cleaved-caspase-1 (D210) detects levels of fragment of activated Caspase-1 protein resulting from cleavage adjacent to D210.
Antibody host:
Rabbit
Clonality of antibody:
Polyclonal
Isotype:
Rabbit IgG
Clone:
N/A
This antibody reacts with:
Human
Immunogene sequence:
Synthesized peptide derived from human Caspase-1 between Ser 129 - Asn 205
Concentration of antibody:
1 mg/ml
Form of antibody:
Liquid
Formulation of this antibody:
50 µl purified antibody supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Purification method:
Affinity purified rabbit IgG
This antibody has been succesfully tested for use in following methods:
Western Blot, Immunohistochemistry, ELISA,
Recommended usage:
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps