anti-MEF2C Antibody

MEF2C

Myocyte-specific enhancer factor 2C, MEF2C

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Rabbit

Polyclonal

Rabbit IgG

N/A

Human

synthetic human MEF2C peptide (Gln 365 – Asp 400)

N/A

Liquid

100 µl antibody supplied in PBS with 0.09% (W/V) sodium azide.

Affinity purified rabbit IgG

Western Blot, Immunofluorescent staining, Immunohistochemistry

Western Blot 1:1000; Immunofluorescent staining 1:10~50; Immunohistochemistry 1:10~50

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps