anti-LGR5 Antibody

LGR5

Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, GPR49, GPR67

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Rabbit

Polyclonal

Rabbit IgG

N/A

Human, Mouse, Rat

synthetic human LGR5 peptide (Ile685 - Pro720)

N/A

Liquid

100 µl antibody supplied in PBS with 0.09% (W/V) sodium azide.

Affinity purified rabbit IgG

Western Blot, Immunofluorescent staining, Immunohistochemistry, Flow cytometry

Western Blot 1:1000; Immunofluorescent staining 1:100; Immunohistochemistry 1:25; Flow cytometry 1:25

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps