anti-Acetyl-Lysine Monoclonal Antibody

Catalog number
A1029-100
Name
anti-Acetyl-Lysine Monoclonal Antibody
Size
Acetyl-Lysine Monoclonal Antibody
Price
371.00 EUR
Supplier

Details

Target of this antibody:
Acetyl Lysine
Alternative names of antibody target:
Acetyl Lysine
Background information:
Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of lysine involves acetylation. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Protein post-translational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization. The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases, and HDACs have become promising targets for anti-cancer drμgs currently in development.
Antibody host:
Mouse
Clonality of antibody:
Monoclonal
Isotype:
Mouse IgG
Clone:
5A1
This antibody reacts with:
Human
Concentration of antibody:
0.2 mg/ml
Form of antibody:
Liquid
Formulation of this antibody:
100 ug (0.2 mg/ml) of antibody in 0.01M Tris-HCl, pH 8.0, 0.15M NaCl, and 0.02% sodium azide.
Purification method:
Affinity purified mouse IgG using protein G
This antibody has been succesfully tested for use in following methods:
WB
Recommended usage:
Western blot
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
Description
N terminal acetylation or CH3CO as epigenetic regulation of anti- -Lysine Monoclonal Antibody by NATs.This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
French translation
anticorps