anti-Anti-TNF-α (Adalimumab), humanized Antibody

TNF-α

Humira

Adalimumab (Humira), a human monoclonal antibody that specifically binds to tumor necrosis factor-alpha (TNF-a). Possessing a high specificity and affinity for TNFα adalimumab exerts its therapeutic effects by blocking the interaction of TNFα with the p55 and p75 receptors as well as inducing apoptosis of TNF-expressing mononuclear cells. Adalimumab can be used for the treatment of Rhcumatoid arthritis, Juvenilc Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Crohn's Disease and Plaque Psoriasis.

Human

Monoclonal

Human IgG1

Human

Recombinant human TNF a

2 mg/ml

Liquid

100 ug (2mg/ml) of antibody in Phosphate buffered saline, pH 7.4.

human IgG1 was expressed in a human cell line. IgG was purified from CHO cell culture supernatant by protein A chromatography.

Neutralization, ELISA

Neutralization : 0.01-1 μg/ml; ELISA: 1μg/ml

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

anticorps