anti-Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody

ITGA5

Fibronectin receptor; CD49 antigen-like family member E; Integrin alpha-F; VLA-5; CD49e

The antibody binds specifically to a5ß1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The a5ß1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.

Recombinant

Monoclonal

Human IgG4, kappa

M200

Human

Heterodimeric α5β1Fc fusion protein

Liquid

200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300

Affinity purified using protein A

ELISA; FC; IF; Block; IHC

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use

The anti-Anti-alpha 5 beta 1 Integrin (Volociximab) IgG4 Antibody is a α- or alpha protein sometimes glycoprotein present in blood.This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

anticorps