anti-Phospho-Cyclin E1 (Thr77) Antibody

Catalog number
A1154-100
Name
anti-Phospho-Cyclin E1 (Thr77) Antibody
Size
Phospho-Cyclin E1 (Thr77) Antibody
Price
403.00 EUR
Supplier

Details

Target of this antibody:
CCNE1
Alternative names of antibody target:
CCNE; G1/S-specific cyclin-E1
Background information:
Cyclin E1 is a regulatory subunit of the CDK2 kinase. It is central for the regulation of the G1/S transition and its abundance is tightly regulated throughout the cell cycle via ubiquitination. Cyclin E has been the subject of intense study in relation to tumorigenesis and cancer management and prognosis. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Antibody host:
Rabbit
Clonality of antibody:
Polyclonal
Isotype:
Rabbit IgG
Clone:
N/A
This antibody reacts with:
Human, Mouse
Immunogene sequence:
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin E1
Form of antibody:
Liquid
Formulation of this antibody:
In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Purification method:
Affinity purified
This antibody has been succesfully tested for use in following methods:
WB, IH, IF/IC
Recommended usage:
WB; 1:500 – 1:2000, IHC; 1:50 – 1:200, IF/IC; 1:50 – 1:100
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps