IGF-BP3, human recombinant

Catalog number
4720-25
Name
IGF-BP3, human recombinant
Size
25 μg
Price
340.00 EUR
Supplier
Biovision
Order

Details

Synonyms
insln-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein
Alternates names
insln-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein
Taglines
A protein which binds and prolongs the half-life of the IGFs
Biomolecule/Target
NA
NCBI Gene ID #.
3486
NCBI Gene Symbol
IBP3
Gene Source
Human
Accession #
P17936
Recombinant
Yes
Source
E. coli
Purity
≥98%
Activity (Specifications/test method)
N/A
Biological activity
The ED₅₀ as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is
Molecular Weight
28.8 kDa
Storage Temp.
-20°C
Shipping
Gel pack
Shelf Life
1 year
Concentration
N/A
Appearance
Lyophilized protein
Physical form description
Sterile filtered and lyophilized from 20 mM HCl
Reconstitution Instructions
Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.
Handling
Centrifuge the vial prior to opening.
Usage
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description
IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.
Additional source
Recombinants or rec. proteins
Group
recombinants