IGF-BP5, human recombinant

Catalog number

4723-1000

Size

1 mg

Price

3000.00 EUR

Supplier

Biovision

Order

Details

Synonyms

insln-like Growth Factor-Binding Protein5

Alternates names

insln-like Growth Factor-Binding Protein5

Taglines

A protein which binds and prolongs the half-life of the IGFs

Biomolecule/Target

NCBI Gene ID #.

3488

NCBI Gene Symbol

IBP5

Gene Source

Human

Accession #

P24593

Recombinant

Yes

Source

E. coli

Purity

≥98%

Activity (Specifications/test method)

N/A

Biological activity

The ED₅₀ as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is

Molecular Weight

28. 6 kDa

Storage Temp.

-20°C

Shipping

Gel pack

Shelf Life

1 year

Concentration

N/A

Appearance

Lyophilized protein

Physical form description

Sterile filtered and lyophilized from 10 mM Sodium Citrate solution, pH 3.0.

Reconstitution Instructions

Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.

Handling

Centrifuge the vial prior to opening.

Usage

For Research Use Only! Not to be used in humans

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Description

IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.

Additional source

Recombinants or rec. proteins

Group

recombinants