Caspase-6 Inhibitor Z-VEID-FMK for cell activation

VEID is the specific recognition sequence for caspase-6/Mch2. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Z-Val-E(OMe)-Ile-Asp(OMe)-FMK

N/A

652.9

Caspase Inhibitor

Z-VEID-FMK, Caspase-6 Inhibitor, VEID-FMK, VEID fluoromethylketone

C₃₁H₄₅FN₄O₁₀

Liquid

In DMSO (2 mM)

No

Yes

>98% by HPLC

N/A

-20°C

gel pack

6-12 months

Protect from light and moisture

cell

Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.