Calpain Inhibitor Z-LLY-FMK for cell activation

A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M⁻¹s⁻¹). Also acts as an inhibitor of cathepsin L (k₂= 680,000 M⁻¹s⁻¹).

Z-Leu-Leu-Tyr-FMK

N/A

557.7

Calpain

Z-LLY-FMK, Calpain Inhibitor(fluoromethylketone)

C₃₀H₄₀FN₃O₆

Liquid

DMSO (10 mM)

No

Yes

>95% by HPLC

N/A

-20°C

gel pack

12 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.