EMAP-II Inhibitor Z-ASTD-FMK for cell activation

A synthetic peptide that irreversibly inhibits EMAP II (Endothelial Monocyte-Activated Polypeptide II) activity released during apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Z-Ala-Ser-Thr-Asp(OMe)-FMK

N/A

556.54

Caspase Inhibitor

Z-ASTD-FMK, Z-ASTD-fluoromethylketone, EMAP-II Inhibitor(fluoromethylketone)

C₂₄H₃₃FN₄O₁₀

Liquid

DMSO (10 mM)

No

Yes

>99% by HPLC

N/A

-20°C

gel pack

12 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.