Caspase-9 Inhibitor, Q-LEHD-OPh for cell activation

A second-generation capase-9 inhibitor that is potent, cell permeable, irreversible and nontoxic.

N/A

N/A

821.82

Caspase Inhibitor

Q-LE(OMe)-HD(OMe)-OPh; Quinolyl-Leu-Glu(OMe)-His-Asp(OMe)-OPh

C₄₀H₄₅F₂N₇O₁₀

Off-white solid

N/A

No

Yes

N/A

DMSO

-20°C

gel pack

24 months

Protect from air and moisture

cell

Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.