Sunitinib Malate (Sutent) for cell activation

Catalog number
1611-100
Name
Sunitinib Malate (Sutent) for cell activation
Size
100 mg
Price
191.00 EUR
Supplier

Details

Description
Sunitinib is a potent inhibitor of CSF-1 receptor kinase in an enzyme assay, with an IC₅₀ of 7 nM, and inhibits receptor phosphorylation in a cellular assay with an IC₅₀ of 61 nM. Sunitinib inhibits SCF-induced phosphotyrosine levels on KIT (IC₅₀ = 1 - 10 nM) and reduced SCF-stimulated ERK1/2 phosphorylation with an IC₅₀ value consistent with that for inhibition of KIT phosphotyrosine levels. Sunitinib also inhibited SCF-stimulated proliferation in NCI-H526 cells (IC₅₀ = 2 nM).
Peptide sequence
N/A
CAS number
341031-54-7
Molecular weight
532.56
Category
Biochemicals
Other name
Sunitinib Maleate, SU-11248, Sutent, PHA-290940AD, PNU-290940AD
Molecular formula
C₂₂H₂₇FN₄O₂.C₄H₆O₅
Physical appearance
Yellow-orange powder
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥99% by HPLC
Reconstitute instructions
DMSO (40 mg/ml)
Storage condition
-20°C
Shipping condition
RT
Maximum time for storage
24months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.