Sunitinib Malate (Sutent) for cell activation

Sunitinib is a potent inhibitor of CSF-1 receptor kinase in an enzyme assay, with an IC₅₀ of 7 nM, and inhibits receptor phosphorylation in a cellular assay with an IC₅₀ of 61 nM. Sunitinib inhibits SCF-induced phosphotyrosine levels on KIT (IC₅₀ = 1 - 10 nM) and reduced SCF-stimulated ERK1/2 phosphorylation with an IC₅₀ value consistent with that for inhibition of KIT phosphotyrosine levels. Sunitinib also inhibited SCF-stimulated proliferation in NCI-H526 cells (IC₅₀ = 2 nM).

N/A

341031-54-7

532.56

Biochemicals

Sunitinib Maleate, SU-11248, Sutent, PHA-290940AD, PNU-290940AD

C₂₂H₂₇FN₄O₂.C₄H₆O₅

Yellow-orange powder

N/A

No

Yes

≥99% by HPLC

DMSO (40 mg/ml)

-20°C

RT

24months

Protect from air and moisture

cell

For cells, cell lines and tissues in culture till half confluency.