ABT-869 for cell activation

ABT-869 is multi-targeted inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR, IC₅₀ value of 4 nM), but has much less activity (IC₅₀ values >1 µM) against unrelated receptor tyrosine kinases, soluble tyrosine kinases or serine/threonine kinases. The kinase inhibition profile of ABT-869 is evident in cellular assays of RTK phosphorylation (IC₅₀ values of 2, 4 and 7 nM for PDGFRβ, KDR and CSF-1R, respectively) and VEGF-stimulated proliferation (0.2 nM IC₅₀ for human endothelial cells).

N/A

796967-16-3

375.41

Biochemicals

Linifanib

C₂₁H₁₈FN₅O

Crystalline solid

N/A

No

Yes

≥99%

DMSO

-20°C

RT

24months

Protect from air and moisture

cell

For cells, cell lines and tissues in culture till half confluency.